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I'M JAMIE KOLBY.
IT'S TIME FOR SUNDAY HOUSECALL.
>> I'M ERIC SHAWN.
JOINING USERING DR.
MARC SIEGEL, ASSOCIATE PROFESSOR OF MEDICINE AT NYU'S LANGAL MEDICAL CENTER AND AUTHOR OF THE INNER PULSE TO UNLOCKING SICKNESS AND HEALTH.
>> AND DR.
DAVID SAMADI IS HERE.
HE'S A PROFESSOR, TOO, AND GREAT TO SEE BOTH OF YOU.
THANK YOU FOR JOINING US.
I WANTED TO BEGIN WITH THIS NEW RESEARCH IN THE FIGHT AGAINST ALZHEIMER'S.
THERE'S A STUDY THAT FINDS DOCTORS MAY SOON BE ABLE TO DETECT THE DISEASE YEARS BEFORE THE FIRST SYMPTOMS SET IN.
DR.
SIEGEL, HOW EARLY? >> THIS IS PRETTY EXCITING.
IT'S OUT OF JOHNS HOPKINS AND PUBLISHED IN A MAJOR JOURNAL CALLED NEUROLOGY AND IT LOOKED AT THE IDEA OF LOOKING AT THE FLUID THAT'S AROUND THE BRAIN, THE CSF, WE CALL IT.
THAT FLUID WE'RE GOING TO TALK ABOUT IN THE SECOND TOPIC AS WELL, BUT IT'S NOT ONLY A CUSHION, BUT IT ABSORBED WASTE PRODUCTS AND PROTEIN FROM THE BRAIN THE BRAIN MAKES WHEN IT'S WORKING.
IF YOU HAVE THESE TWO VERY ABNORMAL PROTEINS, IF THEY BUILD UP IN THE FLUID AROUND THE BRAIN, IT MAY BE A MARKER THAT FIVE YEARS DOWN THE LINE, YOU MIGHT HAVE A PROBLEM THINKING.
YOU MAY BE FORGETFUL, YOU MIGHT HAVE A PROBLEM WITH DAILY ACTIVITIES.
YOU MAY BE ON THE VERGE OF MILD DEMENTIA OR ALZHEIMER'S.
IF WE KNEW FIVE YEARS IN ADVANCE, IF YOU COULD PREDICT FIVE YEARS IN ADVANCE, MAYBE WE COULD COME UP WITH TREATMENTS THAT PREVENT IT BEFORE IT HAPPENS.
THAT'S WHAT WE DO WITH HEART DISEASE.
WE HAVE HIGH BLOOD PRESSURE, WE TREAT THAT IN ADVANCE.
WE'RE HOPING WE CAN TREAT IN ADVANCE AND THIS IS THE FIRST TIME WE HAVE SEEN A MARKER WE CAN FOCUS ON.
>> HOW DO YOU FIND IT? IS THERE A TEST FOR THESE MARKERS? >> THEY'RE LOOKING AT THE RATIO BETWEEN THE PROTEIN AND BETA AMALOID.
THEY'RE COMING UP WITH THIS KIND OF RESULTS AMONG NORMAL, COGNITIVE PEOPLE.
WE'VE HAD THESE RESULTS IN THE PAST ON ALZHEIMER'S PATIENTS, BUT NOW FOR THE FIRST TIME, 265 PATIENTS GO THROUGH NOW SYMPTOMS, NORMAL PEOPLE, AND NOW WITH A FAMILY HISTORY OF ALZHEIMER SKNZ FINDING OUT IF YOU HAVE TOO MUCH OF THE PROTEIN AND NOT ENOUGH BETA AMALOID, THERE'S A HIGH RISK OF HAVING ALZHEIMER'S.
JUST LIKE WE HAVE CHOLESTEROL OR BLOOD PRESSURE, WE CAN PREDICT IT.
IT'S FASCINATING BECAUSE WE CAN SEE WHO IS HEADED TOWARD IT.
WE DON'T HAVE A TREATMENT, THAT'S THE PROBLEM.
THE WAY TO DO THIS IS TO GET THE SPINAL FLUID, AND MORE STUDY NEEDS TO BE DONE TO DUPLICATE THIS.
WHERE ARE WE GOING? $200 BILLION SPENT ON ALZHEIMER'S.
IT'S A HEALTH CRISIS.
IF WE COULD DELAY THIS AND IF WE CAN PUSH IT FURTHER BACK UNTIL THE PHARMACEUTICALS WILL COME UP WITH THIS, WE'LL BE OKAY.
ERIC IS GOING TO -- >> WHAT SHOULD -- ERIC IS GOING TO SAY, WHAT SHOULD I ASK MY DOCTOR FOR? BUT NOT EVERYBODY WANTS SPINAL FLUID.
>> WE'RE NOT READY FOR THAT.
WHAT YOU CAN DO MONDAY MORNING, EVERYTHING IS GOING TO COME TOGETHER.
LISTEN UP.
SATURATED FATS, RIGHT? THAT'S ALL THE MEAT AND DAIRY WE TALK ABOUT.
THAT INCREASES YOUR BETA AMALOID.
ALL THESE DOUGHNUTS AND FOODS WE TALK ABOUT IT, REPLACE THEM WITH VEGETABLES AND BERRIES.
EXERCISE, EXERCISE ACTUALLY CAN REDUCE THE LEVEL OF BETA AMALOID IN YOUR BRAIN, AND FINALLY, SLEEP, WHICH WE'LL TALK ABOUT, IS ALSO GOING TO REDUCE IT.
IF YOU CAN DO IT AT LEAST FOR MONDAY MORNING, YOU HAVE AN OPTION.
>> NOTICE HOW DR.
SAMADI PRONOUNCES THE WORD ALZHEIMER'S.
THAT'S THE CORRECT PRONUNCIATION, AND THINK ABOUT THIS.
THIS IS A LITTLE ON THE NOTHINGATIVE SIDE.
IF YOU KNEW, ERIC, THAT FIVE YEARS FROM NOW, YOU WERE GOING TO HAVE A PROBLEM THINKING OR YOU WERE GOING TO BE FORGETFUL, YOU COULD SAY, LOOK, WE BETTER DO SOMETHING ABOUT THIS NOW.
WHAT'S YOUR HOME SITUATION? WHO ARE YOUR CARE TAKERS? HOW CAN WE PREDICT THE FUTURE? THAT'S A BIG DEAL IN MEDICINE.
>> A LOT OF PATIENTS DON'T WANT TO KNOW IF YOU CAN'T TREAT IT.
>> WE'RE GETTING THERE WITH TREATMENT.
BUT WE WANT THE TREATMENTS EARLY.
>> SPEAKING OF THE BRAIN HEALTH, DO YOU KNOW YOUR BRAIN WHEN IT'S SLEEPING IS ACTUALLY REALLY BUSY WHEN WE'RE ASLEEP.
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