The accumulation of amyloid-β (Aβ) in the brains of Alzheimer's disease (AD) patients is known to be associated with memory loss and neuronal degeneration, but the mechanism of amyloid-β pathogenesis is not fully understood.
In the Journal of Clinical Investigation, researchers led by Yong-Keun Jung at Seoul National University demonstrate that amyloid-β binds to a cellular protein known as FCγRIIb. Greater levels of FCγRIIb were detected in the brains of AD patients. Binding of Aβ to FCγRIIb activated cell stress and death pathways.
In a mouse model of Alzheimer's disease, depletion of FCγRIIb ameliorated memory impairment. This study demonstrates that FCγRIIb plays a critical role in Alzheimer's disease pathogenesis.
TITLE: FCγRIIb mediates amyloid-β; neurotoxicity and memory impairment in Alzheimer's disease
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