After undergoing stem cell transplants as treatment for cancer, two patients with HIV now have no trace of the virus in their systems and haven't required their HIV medication for several weeks, doctors reported today.


However, doctors cautioned that it's still too soon to say that the patients have been definitively cured, as they have only been off their treatments for 15 weeks and seven weeks, respectively.


The research, led by Dr. Timothy Henrich of Harvard Medical School and Brigham and Women’s Hospital in Boston, reported the findings today at the International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention.


"They are doing very well[1] ," Henrich said at the conference, as reported by the Associated Press. "While these results are exciting, they do not yet indicate that the men have been cured. Only time will tell."


The two patients had been HIV positive and had been taking antiretroviral medication for their condition. However, they each developed Hodgkin’s lymphoma (one patient reportedly had other blood cancers as well) and so underwent chemotherapy as well as stem cell transplants while still receiving their antiretroviral medications. The Los Angeles Times[2] reported that the men received their transplants at different times; one four-and-a-half years ago, and the other nearly three years ago. After undergoing the stem cell transplants, the virus is now undetectable.


However, the Associated Press reported that more time is needed[3] to determine if the HIV virus isn't just hiding undetected elsewhere in the body. Dr. Robert Siciliano of Johns Hopkins University explained in a statement that it may take more than a year to make sure viral rebound does not occur, and that doctors will have to continue monitoring the patients.


The first news of these two men came last year at the 2012 International AIDS Conference; back then, they had undetectable HIV levels in their blood plasma[4] , but had not yet been taken off antiretroviral medications.



The approach Henrich and his team have taken is similar to that of Timothy Brown, also known as the "Berlin Patient[5] ," who underwent stem cell transplantation as part of his treatment protocol for leukemia, before being the first person deemed "cured" of HIV[6] . However, in Brown's case, the stem cells transplanted into him were HIV-resistant stem cells, while in the cases of these two men, the stem cells did not have that genetic mutation for HIV resistance. Brown also received a more intensive chemotherapy regimen.


The Los Angeles Times reported that this method -- stem cell transplantation -- is likely to be unfeasible for most HIV-positive people[7] . NBC News pointed out last year that the reason why the approach seemed to work for these men is because they had certain gene mutations that made their immune system cells resistant to HIV infection[8] , and that in general, bone marrow transplants are expensive procedures with a 15 percent fatality rate.


This is just one of the latest HIV treatment breakthroughs that have been reported as of late. Earlier this year, a baby born with HIV was considered "functionally cured," [9] the Associated Press reported. That baby was born to a mother with HIV. The baby was given faster, stronger-than-usual treatment immediately upon birth, even before doctors were able to test that the baby actually was infected with HIV. At the time of the reporting of this news, the child was 2.5 years old and hadn't needed to take antiretroviral medication for a year.


And just after the news of this baby was reported, researchers from France reported the "functional cure" of 14 adults with HIV[10] , who were treated extremely early with combiantion antiretroviral therapy (cART). Now, their HIV levels are barely detectable, and they have been able to stop taking their treatment.




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  • 1. Most Don't Have Their Infection Under Control


    Only one quarter of the 1.1 million <a href="http://www.cdc.gov/nchhstp/newsroom/docs/2012/Stages-of-CareFactSheet-508.pdf">people with HIV</a> have their <a href="http://www.huffingtonpost.com/2012/07/27/hiv-under-control-1-in-4_n_1711260.html">condition under control</a>, where "under control" means the virus has been suppressed, according to a report released this summer by the Centers for Disease Control and Prevention. "Only if we get <a href="http://www.philly.com/philly/health/HealthDay667108_20120727_Only_1_in_4_Americans_With_HIV_Has_Virus_Under_Control__CDC.html">everyone under regular care</a> for HIV/AIDS can we recognize the full benefits of treatment and prevention," Irene Hall, an epidemiologist at the CDC and one of the authors of the report, told HealthDay. <em><strong>CORRECTION</strong>: The first sentence has been reworded to more accurately reflect the number of people with HIV.</em>




  • 2. Bone Marrow Transplants Could Play A Part In Being HIV-Free


    Two men with HIV and cancer no longer have <a href="http://www.huffingtonpost.com/2012/07/26/hiv-free-men-bone-marrow-transplants_n_1707505.html">detectable blood levels of the virus</a> after receiving bone marrow transplants for their cancers, news outlets reported this year. Doctors were unable to <a href="http://www.huffingtonpost.com/2012/07/26/hiv-free-men-bone-marrow-transplants_n_1707505.html">find any traces of HIV</a> in the men's cells after they received the bone marrow transplants while also being treated with antiretrovirals. The finding "suggests that under the <a href="http://abcnews.go.com/blogs/health/2012/07/26/two-more-patients-hiv-free-after-bone-marrow-transplants/">cover of anti-retroviral therapy</a>, the cells that repopulated the patient's immune system appear to be protected from becoming re-infected with HIV," Dr. Timothy Henrich, of Brigham and Women's Hospital, told ABC News. However, the Boston Globe pointed out that it's still too soon to say that these men have been<a href="http://www.huffingtonpost.com/2012/07/26/hiv-free-men-bone-marrow-transplants_n_1707505.html"> full-on <em>cured</em></a> of HIV, since they are still on the anti-retrovirals. There's no firm word on whether they will go off of the medication.




  • 3. No-Cost HIV Treatment Could Cut New Infection Rates


    New <a href="http://www.huffingtonpost.ca/2012/11/27/free-hiv-drugs-decrease-infection-bc_n_2200393.html">HIV infection rates</a> can be dramatically lowered by making antiretroviral drugs free, a study from Canadian researchers found. The Canadian Press reported on the study, conducted by B.C. Centre for Excellence in HIV-AIDS researchers, which showed that British Columbia -- a province that offers <a href="http://www.huffingtonpost.ca/2012/11/27/free-hiv-drugs-decrease-infection-bc_n_2200393.html">free access to antiretroviral therapy</a> -- had the lowest rate of new HIV infections over a more-than-10-year period, compared with Ontairio and Quebec.




  • 4. Many Young People Don't Know Their HIV Status


    More than half of HIV-infected young people are <a href="http://www.huffingtonpost.com/2012/11/27/hiv-youths-infected-aids-young-people_n_2198629.html">unaware that they have the virus</a>, according to a Centers for Disease Control and Prevention report. "Given everything we know about HIV and how to prevent it in 30 years of fighting the disease, it's just unacceptable that young people are <a href="http://www.huffingtonpost.com/2012/11/27/hiv-youths-infected-aids-young-people_n_2198629.html">becoming infected at such high rates</a>," Reuters reported CDC Director Dr. Thomas Frieden saying. The report also showed that for young people, 72 percent of the new HIV infections were in men who have sex with men, while almost 50 percent were in young, African-American males, Reuters reported. These figures are based on 2010 data.




  • 5. More People Are Living With HIV Than 10 Years Ago


    The number of people <a href="http://www.huffingtonpost.com/2012/07/18/hiv-aids-numbers-statistics-worldwide_n_1682936.html">living with HIV</a> has increased by 18 percent from 2001 to 2011, according to a report released this year from the United Nations Programme on AIDS. An estimated 34.2 million people around the world are living with HIV. The report also showed that <a href="http://www.huffingtonpost.com/2012/07/18/hiv-aids-numbers-statistics-worldwide_n_1682936.html">deaths from AIDS </a>have <em>dropped</em>, from 2.3 million in 2005-2006 to 1.7 million in 2011, Reuters reported.




  • 6. The Cost Of HIV Drugs Is Decreasing


    According to the same United Nations report, costs for the cheapest UN-recommended <a href="http://www.huffingtonpost.com/2012/07/18/hiv-aids-numbers-statistics-worldwide_n_1682936.html">antiretroviral therapy drugs</a> have also decreased over the past 10 years, Reuters reported. A year's worth of the drugs used to cost $10,000 in 2000 for one person; now, it costs $100 a year.




  • 7. HIV Treatment Truvada Can Also Be Used As A Preventive Measure


    The Food and Drug Administration this year officially approved the <a href="http://www.huffingtonpost.com/2012/08/09/truvada-heterosexuals-aids-hiv-prevention-pill_n_1760542.html">drug Truvada</a> -- which has been used since 2004 as a treatment for HIV -- to be sold as a preventive measure for people who don't have the infection, but are at high risk for it. The FDA said that the pill should be considered for <a href="http://www.huffingtonpost.com/2012/08/09/truvada-heterosexuals-aids-hiv-prevention-pill_n_1760542.html">preventive use</a> not only by gay or bisexual men who are at high risk for HIV, but also heterosexual men and women who may also face HIV risks, the Associated Press reported. <a href="http://www.huffingtonpost.com/2012/08/09/truvada-heterosexuals-aids-hiv-prevention-pill_n_1760542.html">Heterosexual men and women</a> make up more than one-fourth of new cases of HIV, and "that's not a portion of the epidemic we want to ignore," the CDC's Dr. Dawn Smith, who was the lead author of the new recommendations, told the Associated Press. The FDA also approved a new drug this year, <a href="http://www.huffingtonpost.com/2012/08/27/stribild-hiv-treatment-fda_n_1834734.html">Stribild</a>, to treat HIV, Reuters reported.




  • 8. Engineered Stem Cells Could Play A Part In Fighting HIV


    In findings published this year in the journal <em>PLoS Pathogens</em>, scientists from the University of California, Los Angeles found that it's possible to <a href="http://www.huffingtonpost.com/2012/04/16/stem-cell-aids-hiv-study-ucla_n_1428660.html">genetically engineer stem cells</a> to attack living HIV-infected cells in mice. While the study was only for "proof-of-principle," it "lays the groundwork for the potential use of this type of an approach in combating HIV infection in infected individuals, in hopes of eradicating the virus from the body," study researcher Dr. Scott G. Kitchen, an assistant professor of medicine at UCLA, said in a statement.




  • 9. Pretty Much Everyone Should Be Screened For HIV


    People should be screened for HIV even if they're not at high risk of contracting the infection, according to draft recommendations released just last month by the U.S. Preventive Services Task Force. The recommendations would mean that everyone between the ages of 15 and 65 should be <a href="http://www.huffingtonpost.com/2012/11/19/routine-hiv-screening-us-preventive-services-task-force-uspstf_n_2161090.html">screened for HIV</a>, even if they're not at high risk for it, Reuters reported. "The prior recommendations were for screening high-risk adults and adolescents," Dr. Douglas Owens, a member of the USPSTF task force and a Stanford University medical professor, told Reuters. "The current recommendation is for <a href="http://www.huffingtonpost.com/2012/11/19/routine-hiv-screening-us-preventive-services-task-force-uspstf_n_2161090.html">screening everyone</a>, regardless of their risk."




  • 10. People Should Be Treated With Antiretrovirals As Soon As They're Diagnosed WIth HIV


    <em>All</em> HIV patients should be <a href="http://healthland.time.com/2012/07/23/new-advice-calls-for-putting-all-hiv-patients-on-drug-treatment/">treated immediately with antiretrovirals</a>, according to new guidelines issued this year from a panel of the International Antiviral Society-USA, as reported by <em>TIME</em>. The recommendations are counter to previous guidelines, which said that antiretrovirals should only be used if the CD4 count -- a measure of immune cells in a person's body -- becomes less than 350 cells for every mm3 of blood.




  • Growing Up with HIV


    During the AIDS 2012 conference, Christina Rodriguez talks about growing up with HIV.