Antibiotics can sometimes come with a nasty side effect -- diarrhea. But a new review of studies shows that taking probiotic supplements could help to reduce your chance of experiencing this uncomfortable condition.


Antibiotic-related diarrhea occurs when harmful bacteria, such as Clostridium difficile, take up residence in the gut, crowding out other good bacteria. While mild cases often go away on their own, the effects cause discomfort and can sometimes progress to more serious cases, even leading to conditions such as colitis or pseudomembranous colitis, according to the Mayo Clinic.


"In the short-term, taking probiotics in conjunction with antibiotics appears to be a safe and effective way of preventing diarrhoea associated with Clostridium difficile infection," study researcher Bradley Johnston, of The Hospital for Sick Children Research Institute in Canada, said in a statement.


However, he added that more research is needed to determine the most effective probiotic strains and doses, as well as to see if probiotics are safe to take for this purpose for people with compromised immune systems.


The review, published in The Cochrane Collaboration, included data from a total of 4,213 people who were involved in 23 different trials. Researchers found that when people took probiotics in addition to their antibiotics, they had a 64 percent lower risk of having Clostridium difficile-associated diarrhea, compared with people not taking the probiotics. The researchers noted that taking probiotics with antibiotics seemed to decrease the risk of side effects.


"Moderate quality evidence supports a large protective effect of probiotics in preventing CDAD, but not in reducing the incidence of Clostridium difficile infection," the researchers wrote in the study. "Stated in absolute terms, probiotic prophylaxis would prevent 35 CDAD [Clostridium difficile-associated diarrhea] episodes per 1,000 patients treated."


In addition to probiotics, the Mayo Clinic advises other preventive measures against antibiotic-related diarrhea, including only taking antibiotics when you absolutely have to, making sure your doctor knows if you have a history of antibiotic-related diarrhea, and asking caregivers if they've washed their hands (so that they don't spread any Clostridium difficile bacteria to you).


Recently, a study in the journal Gastroenterology showed that probiotics could also help with stress-related gut inflammation. For more benefits of probiotics, click through the slideshow:





  • Digestive Health


    Each of us has more than 1,000 different types of bacteria that live in our digestive tracts, helping us to break down food and absorb nutrients. But when we take antibiotics -- medicine that is designed to kill destructive, illness-causing bacteria -- the drugs can also kill the healthy intestinal flora that helps us digest. About 30 percent of the patients who take antibiotics report suffering from diarrhea or some other form of gastrointestinal distress, according to the recent <em>JAMA</em> study on probiotics and antibiotic-associated diarrhea. As a result, doctors commonly prescribe taking probiotics to "repopulate" the digestive tract with healthful bacteria. The study found that it was a viable solution for many.
    <br><br>
    But probiotics can also help with other types of digestive issues. <a href="http://www.ncbi.nlm.nih.gov/pubmed/16863564" target="_hplink">Research has shown</a> that probiotics can be helpful for people with irritable bowel syndrome, or IBS -- a hard-to-treat condition that can have a range of intestinal symptoms, such as abdominal pain, cramps, bloating, diarrhea and constipation. In one study, female IBS patients experienced some alleviation of symptoms like abdominal pain and irregularity when they were given a supplement of the bacterial strain, Bifidobacterium infantis.
    <br><br>
    Even for those without an urgent problem, probiotics can help with overall digestive management. Challa argues in his book, <em>Probiotics For Dummies</em>, that good bacteria help "crowd out" bad bacteria. That's because the intestine is lined with adherence sites where bacteria latches on. If the sites are populated with good-for-you microbes, there's no place for a harmful bacterium to latch on.




  • Urinary Health


    Probiotics make a nice compliment to antibiotics among people who suffer from urinary tract infections, <a href="http://www.ncbi.nlm.nih.gov/pubmed/16827601" target="_hplink">according to the research</a>.
    <br><br>
    What's more, there's emerging evidence that regular probiotics can help <em>prevent</em> bad bacteria from invading the urinary tract by maintaining a population of healthy bacteria on the tract's adherence sites.
    <br><br>
    Infections of the urinary tract are extremely common, especially in women. Most infections disappear with antibiotics, but about 30 to 40 percent might return, <a href="http://www.umm.edu/altmed/articles/urinary-tract-000169.htm" target="_hplink">according to literature</a> from the University of Maryland Medical Center.




  • Allergies


    Allergy research is still preliminary, but at least one <a href="http://abcnews.go.com/Technology/AllergiesNews/story?id=4727318&page=1#.T7FHU59Ytvd" target="_hplink">large, high quality study</a> found a relationship between women taking probiotics during pregnancy and a 30 percent reduction in the instance of childhood eczema (an early sign of allergies) in their infants.
    <br><br>
    Researchers selected women who had a history of seasonal allergies -- or whose partners had histories of allergies. The infants who received probiotics in-vitro also had 50 percent higher levels of tissue inflammation, which is thought to trigger the immune system and reduce allergy incidence.




  • Women's Health


    Just like the digestive tract, the vagina relies on a precarious balance of good and bad bacteria. When that balance is off, it can result in one of two very common, though thoroughly uncomfortable infections: bacterial vaginosis and yeast infections. In fact, bacterial vaginosis can actually <em>lead</em> to a yeast infection.
    <br><br>
    Some small studies have found that <em>L. acidophilius</em> can help prevent infection, manage an already active one or support antibiotics as a treatment, though it's worth noting that the probiotics were taken as vaginal suppositories, rather than orally in food.
    <br><br>
    Probiotics may also have a special role in maternal health, as pregnant women are particularly susceptible to vaginal infections. And bacterial vaginosis has been indicated as a contributing factor to pre-term labor, making probiotics a potential boon for fetal health.




  • Immunity


    Surprisingly, <a href="http://www.med.umich.edu/opm/newspage/2006/hmprobiotics.htm" target="_hplink">one of the main functions</a> of healthful bacteria is to stimulate immune response.
    <br><br>
    By eating probiotic-rich foods and maintaining good intestinal flora, a person can also help to maintain a healthy immune system. And that has real world effects: for example, in <a href="http://www.ncbi.nlm.nih.gov/pubmed/15309418" target="_hplink">one small study</a> of students, those who were given a fermented dairy drink (instead of milk) displayed increased production from lymphocytes -- a marker of immune response.




  • Obesity


    In 2006, Stanford University researchers found that obese people had different gut bacteria than normal-weighted people -- a first indication that gut flora plays a role in overall weight.
    <br><br>
    Some preliminary research shows that probiotics can help obese people who have received weight loss surgery to maintain weight loss. And in a study of post-partum women who were trying to lose abdomnial fat, the addition of <em>lactobacillus</em> and <em>bifidobacterium</em> capsules helped reduce waist circumference.
    <br><br>
    It's still unclear how probiotics play a role in weight loss -- and there is some controversy about <a href="http://scienceblogs.com/obesitypanacea/2010/03/are_probiotics_the_cure_for_ab.php" target="_hplink">how significant the probiotics-associated weight loss is</a>.
    <br><br>
    But as long as the probiotics source is low-calorie and healthful, itself, it is an innocuous method to attempt.





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